Glomerulopathy with Homozygous Apolipoprotein E2: A Report of Three Cases and Review of the Literature
نویسندگان
چکیده
Most cases of type III hyperlipoproteinemia are accounted for by apolipoprotein E2 (apoE2) homozygotes, a genetic mutation of apoE (Arg158Cys). Glomerulopathy with homozygous apoE2 is rare and characterized by marked foam cell infiltration in the glomerular capillaries and mesangium. Here, we report 3 cases of apoE2 homozygote glomerulopathy diagnosed by renal biopsy and DNA analysis. All 3 cases were middle-aged or elderly males complicated with diabetes for at least a decade. The kidney biopsies showed massive foam cell infiltration in the glomerular capillaries and expanded mesangium accompanied by histological findings of diabetic glomerulosclerosis. The lipid profiles showed type III hyperlipoproteinemia and phenotypic/genetic analyses revealed homozygosity of apoE2. Two of the cases showed nephrotic proteinuria and progressed to renal failure in 3 and 8 years after the diagnosis of kidney disease.
منابع مشابه
Primary Lymphoma of Appendix: Report of Three Cases and Review of Literature
Lymphomatous involvement of the appendix is rare and most of them are found accidentally from appendectomies to treat appendicitis. Here we report three cases of primary lymphoma of appendix of 10 year-old boy, 23-year-old man and 24-year-old woman that presented with abdominal pain to our hospital and the tumors were discovered during routine appendectomy for suspected "appendicitis". Our case...
متن کاملGallbladder volvulus: Review of the literature and report of three cases
Torsion of the gallbladder is a relatively rare surgical disease which mimics acute cholecystitis' symptoms that usually would not be respondable to medical therapies. The torsion would mostly be diagnosed intra-operatively. Cholecystectomy is the treatment of choice. In general in our centre, General Surgery department, Imam Reza hospital, Mashhad, Iran, since 1986 over 14000 cholecystect...
متن کاملMultifocal Primary Non- Hodgkin’s Lymphoma of the Oral Cavity: Report of Three Cases and Review of the Literature
Objective: Oral non- Hodgkin’s lymphoma (NHL) is a relatively rare neoplasm that may develop in the soft tissues or jaw bones, with or without node or marrow involvement. Oral lymphomas are often difficult to diagnose as there are no characteristic clinical features and usually appear as non-tender swellings. Case: We describe clinical, radiographic, histopathological and immunohistochemica...
متن کاملAsterixis as a Focal Neurologic Sign: Report of Three Cases and Literature Review
Asterixis, firstly described in metabolic encephalopathies, may occur unilaterally in patients with various focal brain diseases. Although hardly localizing, most reported cases have showed a contralateral thalamic pathology; but Lesions in the medial frontal lobe, parietal lobe, brain stem, basal ganglia, insular lesions, may also cause unilateral asterixis. In this article, three cases of acu...
متن کاملPONCET\'S DISEASE: A REPORT OF FOUR CASES AND REVIEW OF THE LITERATURE
Four cases of polyarthritis concomitant with active tuberculosis is reported. In three patients pulmonary tuberculosis was confirmed by identification of Mycobacterium tuberculosis in the sputum and bronchoalveolar lavage specimens, and in another one tuberculous lymphadenitis was confirmed by excisional biopsy. In all patients arthritis resolved by tuberculosis treatment and did not recur ...
متن کامل